Genkwanin improves inflammatory injury in rats with septic lung injury by regulating NF-κB signaling pathway
نویسندگان
چکیده
To assess possible effects of genkwanin (GKA) in septic lung injury and its related mechanisms. An animal model cecal ligation puncture (CLP)-induced acute was constructed. Histological analysis wet–dry (W/D) ratio the tissue were observed. The cell apoptosis this analyzed by caspase activity detection, protein levels B-cell lymphoma 2 (Bcl-2) Bcl-2-associated X (Bax), inflammation CLP model; after GKA treatment, it enzyme-linked-immunosorbent serologic assay (ELISA). involvement nuclear factor kappa B (NF-κB) signaling pathway evaluated Immunoblot assay. We constructed an CLP-induced injury. Our data revealed that reduced edema mice. In addition, Mechanically, our addition confirmed improved inflammatory mice regulating NF-κB pathway. therefore could serve as a promising drug for treatment sepsis-induced
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ژورنال
عنوان ژورنال: Quality Assurance and Safety of Crops & Foods
سال: 2022
ISSN: ['1757-837X', '1757-8361']
DOI: https://doi.org/10.15586/qas.v14i2.991